Clinical Trial: Is Pentoxifylline Able to Improve Olfactory Sensitivity?

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Agapurin Retard Used in Patients With Smell Disorder- A Post-marketing Observational Study

Brief Summary: Signal processing in the olfactory neuron could be influenced by inhibition of enzymes like phosphodiesterase. Pentoxifylline is a unspecific phosphodiesterase inhibitor. The hypothesis is that pentoxifylline could lead to increased sensitivity to odors.

Detailed Summary: Olfactory signal processing is conducted by a G-protein linked increase of intracellular concentration of adenosine 3´,5´-cyclic monophosphate (cAMP). In the cilia of olfactory sensory neurons (OSN) cAMP is degraded by phosphodiesterase 1C2 (PDE1C2). Inhibition of PDE1C2 could result in an increased response of OSN to chemical stimuli. Aim of the present prospective post-marketing surveillance study was to investigate the impact of pentoxifylline, an unspecific phosphodieasterase inhibitor, on olfactory function.
Sponsor: Technische Universität Dresden

Current Primary Outcome: TDI-score [ Time Frame: at day 0 and follow up after 3 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome: odor threshold odor discrimination odor identification [ Time Frame: at day 0 and at follow up after 3 weeks ]

Original Secondary Outcome: Same as current

Information By: Technische Universität Dresden

Dates:
Date Received: April 16, 2008
Date Started: November 2009
Date Completion:
Last Updated: February 4, 2016
Last Verified: February 2016