Clinical Trial: Confrontation Phenotypes and Genotypes of Epithelial Odontogenic Tumors of the Jaws
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Confrontation Phenotypic (Clinical, Radiological, Histological) and Genotypic Epithelial Odontogenic Tumors Isolated or Syndromic Jaws
Brief Summary:
Systematically compare the phenotype and genotype of epithelial odontogenic tumors in children and adults with a clinical, radiographic, pathologic and molecular level.
Either:
establish an observatory of this multidisciplinary tumor establish a tumor bank annotated scale unparalleled testing pathophysiological hypotheses search for prognostic factors.
Detailed Summary:
This is an observational study with retrospective and prospective parts. In retrospective part be included the Patients followed between 1992 and January 2011.
In prospective part will follow the Patients will be included after the starting of study.
There are 2 centers :
- st center is in the service of Stomatology and Maxillofacial Surgery in the Pitie Salpetriere Hospital.
- nd center is in the service of Maxillofacial Surgery in hospital Armand Trousseau.
Number of patients include in the part retrospective :
Center N°1-300adults Center N°2-90childrens
Number of patients include in the part prospective :
Center N°1- 90 Center N°2- 30
Duration of study is 3 years Duration of inclusion is 32 months Each patient will be followed for 4 months and for further up to 3 years from the first patient included.
We envision a next circuit : obtaining consent, preoperative consultation,surgery, postoperative consultation N°1, postoperative consultation N°2, genetics consultation and monitoring of patients in 6;12;18;24 months from surgery of tumor and limited in 3 years from th 1st patient included.
Sponsor: Assistance Publique - Hôpitaux de Paris
Current Primary Outcome: Phenotypic and genotypic lines connected to the epithelial odontogenic tumours [ Time Frame: Month 24 from the surgery date ]
In particular, to define the link between the genotype PTCH1, the size of the tumor, its osteolytic character and the predictive factors of recurrence.
Data collection at M6, M12, M18, M24 from the surgery date
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Assistance Publique - Hôpitaux de Paris
Dates:
Date Received: June 13, 2014
Date Started: January 2011
Date Completion:
Last Updated: April 23, 2015
Last Verified: April 2015
