Clinical Trial: Effect of Aerobic Training in Patients With Oculopharyngeal Muscular Dystrophy

Study Status: Not yet recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Effect of Aerobic Training in Patients With Oculopharyngeal Muscular Dystrophy

Brief Summary:

The investigators want to investigate if patients with Oculopharyngeal Muscular Dystrophy can improve fitness by home-training on a cycle ergometer 30 minute, 3 times a week for 10 weeks.

Participants will be evaluated on maximal oxygen consumption and maximal workload measured by an incremental test at baseline and at the end of the exercise period.


Detailed Summary:
Sponsor: Rigshospitalet, Denmark

Current Primary Outcome: Efficacy based on VO2max [ Time Frame: 10 weeks ]

Difference in VO2max measured before and after intervention


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • SF-36 Questionaire [ Time Frame: 10 weeks ]
    Changes in self-rated health from baseline to end of intervention
  • 6 minute walk test [ Time Frame: 10 weeks ]
    Changes in walking distance from baseline to end of intervention
  • Intensity in maximal load (Watt) [ Time Frame: 10 weeks ]
    Changes in maximal load (watt) in the VO2max-test from baseline to end of intervention.
  • Level of plasma creatine kinase [ Time Frame: 10 weeks ]
    Marker for exercise-induced muscle damage. Taken week 0,3 and 10.
  • Level of plasma myoglobin [ Time Frame: 10 weeks ]
    Marker for excercise-induced muscle damage, taken week 0, 3 and 10.
  • 6 minute walk test [ Time Frame: 10 weeks ]
    Changes in walking distance in the test from baseline to end of intervention.
  • A five-time-repetition-sit-to-stand-test [ Time Frame: 10 weeks ]
    Changes in time of five repetitions from baseline to end of intervention
  • A 14-step-stair-test [ Time Frame: 10 weeks ]
    Changes in time completing the test from baseline to end of intervention
  • Dynamometry [ Time Frame: 10 weeks ]
    Changes in external force production from baseline to end of intervention. Dynamometry are measured on hip flexion, dorsal foot flexion, plantar foot flexion, knee flexion, knee extension, and elbow flexion.


Original Secondary Outcome: Same as current

Information By: Rigshospitalet, Denmark

Dates:
Date Received: June 4, 2014
Date Started: February 2014
Date Completion: February 2015
Last Updated: June 5, 2014
Last Verified: June 2014