Clinical Trial: Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis

Brief Summary: Ocular toxoplasmosis (OT) is a major cause of visual impairment worldwide. OT is responsible for 30 to 50% of posterior uveitis. It is characterized by dormant infections that may reactivate without known reasons, causing severe irreversible visual loss. The overall recurrence rate of OT in Europe is greater than 80% for patients and may range from one episode to 11 episodes (1% of OT) in the most extreme cases. Current treatments do not reduce the risk of recurrences and the risk of toxoplasmosis recurrence cannot be predicted in these immunocompetent patients. These clinical and biological expression changes might be related to an individual genetic susceptibility of each patient. The advanced analysis of the entire genome now possible to consider the project.

Detailed Summary:
Sponsor: University Hospital, Strasbourg, France

Current Primary Outcome: Highlighting of genetic mutations associated with the susceptibility to Toxoplasma gondii.severe eye recurrences. Mutation analysis will be done by exome sequencing of the subjects included in this study [ Time Frame: This analysis will be performed on a blood sample taken in patients included in the inclusion visit ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University Hospital, Strasbourg, France

Dates:
Date Received: August 8, 2016
Date Started: October 2016
Date Completion:
Last Updated: August 8, 2016
Last Verified: August 2016