Clinical Trial: Frontoparietal Priority Maps as Biomarkers for MTBI

Study Status: Enrolling by invitation
Recruit Status: Enrolling by invitation
Study Type: Observational

Official Title: Frontoparietal Priority Maps as Biomarkers for MTBI

Brief Summary: The purpose of this study is to determine whether there is a quantitative relationship between brain processes seen by a MRI and visual deficits caused by mild to moderate traumatic brain injuries (mTBI).

Detailed Summary: Participants with mTBI, as well as healthy control participants, will be invited to participate in up to two study visits. Both visits will occur at the University of Minnesota's Center for Magnetic Resonance Research (CMRR). The first study visit will entail (1) interviews to determine the presence of (and, if present, the severity of) oculomotor difficulties such as convergence insufficiency, and (2) behavioral measures (e.g., visually track a moving dot) to assess skill at allocating spatial attention. For participants who have not before participated in an MRI study at the CMRR, a 15-minute scan to acquire research-quality anatomical images of the brain will be acquired at the end of the first visit. A subset of the approximately 88 participants who participate in Visit 1 will be invited to participate in Visit 2. Visit 2 will be dominated by a 90-minute scanning session in the 7 Tesla scanner, during which participants will perform a 10-minute spatial attention task and a 10-minute eye movement task, and high-resolution diffusion tensor imaging data will be acquired while participants enjoy the movie of their choice in the scanner.
Sponsor: University of Minnesota - Clinical and Translational Science Institute

Current Primary Outcome: oculomotor performance [ Time Frame: study enrollment / baseline ]

Oculomotor performance will be measured with behavioral questionnaires, eye-charts, and computerized eye-tracking while subjects perform saccades and smooth pursuit motions.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • frontoparietal priority maps [ Time Frame: baseline ]
    Functional MRI data will be collected at 7 Tesla while subjects perform spatial attention and eye movement tasks.
  • white matter integrity [ Time Frame: baseline ]
    Diffusion tensor imaging data will be acquired at 7 Tesla and analyzed in a priori regions of interest adjacent to frontal and parietal functional regions of interest.


Original Secondary Outcome: Same as current

Information By: University of Minnesota - Clinical and Translational Science Institute

Dates:
Date Received: September 22, 2014
Date Started: July 2015
Date Completion: October 2016
Last Updated: December 4, 2015
Last Verified: December 2015