Clinical Trial: Role of the Renin Angiotensin Aldosterone System in the Mechanisms of Transition to Heart Failure in Abdominal Obesity

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Role of the Renin Angiotensin Aldosterone System and Remodeling of the Matrix Cardiac Extra Cellular in the Mechanisms of Transition to Heart Failure in Abdominal Obesity:

Brief Summary: R2C2 study has shown that abdominal obesity is associated with a cardiac and vascular remodelling in healthy volunteers. This remodelling is correlated with renin-angiotensin aldosterone system (RAAS) activation and/or systemic fibrosis. R2C2 II study is designed to confirm the hypothesis that RAAS is associated with an early remodelling and implicated in the transition to cardiac failure in abdominal obesity.

Detailed Summary: Follow up of abdominal obesity patients from the R2C2 cohort study.
Sponsor: Central Hospital, Nancy, France

Current Primary Outcome: cardiac extracellular matrix remodelling [ Time Frame: 3-7 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Cardiac and arterial phenotype [ Time Frame: 3-7 years ]

Original Secondary Outcome: Same as current

Information By: Central Hospital, Nancy, France

Dates:
Date Received: October 26, 2012
Date Started: November 2012
Date Completion:
Last Updated: August 21, 2015
Last Verified: August 2015