Clinical Trial: A Trial of Rehabilitation in Obesity Hypoventilation Syndrome (OHS)

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title:

Brief Summary: Obesity is an escalating problem in the UK and a proportion of these patients have a condition known as Obesity Hypoventilation Syndrome (OHS). This syndrome is associated with symptoms of breathlessness, reduction in exercise capacity, fatigue and headaches. Previous research has shown that patients with this condition tend to use healthcare services more frequently and are often at risk of other diseases such as diabetes mellitus and high blood pressure. Currently, the mainstay of treatment is noninvasive ventilation (NIV), this is a mask ventilator that patients use overnight to improve oxygen levels and remove carbon dioxide (the waste gas of breathing), however this does not fully treat the underlying problem. The research group has shown that NIV helps improve activity and contributes to weight loss in this group of patients. The aim of this research will be to investigate the effect of an exercise and nutrition programme in addition to NIV on weight loss and activity levels compared to NIV alone.

Detailed Summary:
Sponsor: Guy's and St Thomas' NHS Foundation Trust

Current Primary Outcome: % Weight loss [ Time Frame: 12 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: 6 minute walk test [ Time Frame: 12 months ]

Original Secondary Outcome: Same as current

Information By: Guy's and St Thomas' NHS Foundation Trust

Dates:
Date Received: November 30, 2011
Date Started: November 2011
Date Completion:
Last Updated: August 16, 2015
Last Verified: August 2015