Clinical Trial: Genome-Wide Association Study in Patients With Nontuberculous Mycobacterial Lung Disease

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: Elucidation of Genetic Susceptibility of Patients With Nontuberculous Mycobacterial Lung Disease Using Genome-Wide Association Study

Brief Summary: The aim of this study was to elucidate genetic susceptibility of patients with nontuberculous mycobacterial lung disease using genome-wide association study.

Detailed Summary: Nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms. NTM lung disease is increasing, however, genetic susceptibility of patients with the disease have not been identified. To elucidate the genetic susceptibility of NTM lung disease, the investigators perform a genome-wide association study (GWAS) including patients with NTM lung disease and healthy controls (case : control = 1 : 3). The age-, sex-matched control group will be recruited from the Korean Healthy Twin Study.
Sponsor: Seoul National University Hospital

Current Primary Outcome: Finding of single nucleotide polymorphisms (SNPs) associated with the risk of NTM lung disease compared with controls [ Time Frame: Baseline ]

To identify SNPs related to NTM lung disease using logistic regression after controlling for confounders (GWAS statistical significance threshold, P < 5.00*E-08)


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Finding of SNPs associated with the risk of severe NTM lung disease compared with controls [ Time Frame: Baseline ]
    To identify SNPs related to severe NTM lung disease compared with controls using logistic regression after controlling for confounders (GWAS statistical significance threshold, P < 5.00*E-08)
  • Finding of SNPs associated with the risk of severe NTM lung disease compared with mild NTM lung disease [ Time Frame: Baseline ]
    To identify SNPs related to severe NTM lung disease compared with mild NTM lung disease using logistic regression after controlling for confounders (GWAS statistical significance threshold, P < 5.00*E-08)
  • Finding of SNPs associated with the risk of Mycobacterium avium complex lung disease versus M. abscessus lung disease versus controls [ Time Frame: Baseline ]
    To identify SNPs related to Mycobacterium avium complex lung disease versus M. abscessus lung disease versus controls using multinomial logistic regression after controlling for confounders (GWAS statistical significance threshold, P < 5.00*E-08)


Original Secondary Outcome: Same as current

Information By: Seoul National University Hospital

Dates:
Date Received: July 3, 2016
Date Started: July 2016
Date Completion: August 2019
Last Updated: July 11, 2016
Last Verified: July 2016