Clinical Trial: The Effect Of Omega-3 Fatty Acids on Non-alcoholic Fatty Liver Disease

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Effect Of Omega-3 Fatty Acids on Non-alcoholic Fatty Liver Disease

Brief Summary: There is preliminary evidence that Omega 3, a compound naturally found in fish oil, reduces the amount of fat stored in the liver and improves liver function. The purpose of this study is to see whether this observation is correct.

Detailed Summary:
Sponsor: University of Edinburgh

Current Primary Outcome: Liver appearance on ultrasound [ Time Frame: 6 months ]

The primary endpoint is improvement in grading on ultrasound assessment at six months. Liver brightness and posterior attenuation on ultrasound has previously been shown to correlate significantly with fat scores on liver biopsy.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Liver function tests [ Time Frame: 6 months ]
    the effect of omega-3 fatty acids on serum liver function tests will be assessed following 6 months of treatment.
  • hepatocyte mitochondrial function [ Time Frame: 6 months ]
    heptocyte mitochondrial function will be measured by breath testing following 6 months of omega-3 supplementation
  • Health-related Quality of Life [ Time Frame: 6 months ]
    Health related quality of life scores will be compared with baseline following 6 months of omega-3 supplementation


Original Secondary Outcome: Same as current

Information By: University of Edinburgh

Dates:
Date Received: January 13, 2011
Date Started: September 2010
Date Completion:
Last Updated: January 22, 2014
Last Verified: December 2010