Clinical Trial: Alpha-blocker Plus Diuretic Combination Therapy as Second-line Treatment for Nocturia in Men

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Alpha-blocker Plus Diuretic Combination Therapy as Second-line Treatment for Nocturia in Men With LUTS: a Pilot Study

Brief Summary: The aim of the present study was to determine whether the combined administration of a diuretic agent, hydrochlorothiazide, at night would improve the frequency of nocturia unresponsive to alpha-blocker monotherapy in men with LUTS.

Detailed Summary: Because nocturia may result in sleep disturbances, daytime fatigue, a lower level of general well-being, and an increased risk of falling at night, it is among the most bothersome of the lower urinary tract symptoms (LUTS). Nocturia is related to a variety of conditions such as aging, overactive bladder (OAB), benign prostatic hyperplasia (BPH)/LUTS, medications, diabetes mellitus, diabetes insipidus, anorexia nervosa, and sleep disturbance. In a previous study, we suggested that treatment with terazosin can reduce episodes of nocturia, both subjectively and objectively, in some men with LUTS. Other study showed that in men with nocturnal polyuria, furosemide resulted in a significant reduction in night-time frequency and percentage of the voided volume.
Sponsor: Seoul National University Hospital

Current Primary Outcome: 3-day frequency-volume chart [ Time Frame: at baseline and at the end of the 4-week therapy ]

Original Primary Outcome: Same as current

Current Secondary Outcome: International Prostate Symptom Score (IPSS) question 7 [ Time Frame: at baseline and at the end of the 4-week therapy ]

Original Secondary Outcome: Same as current

Information By: Seoul National University Hospital

Dates:
Date Received: June 16, 2008
Date Started: May 2008
Date Completion:
Last Updated: May 9, 2011
Last Verified: May 2011