Clinical Trial: rTMS as a Treatment of Visceral Pain Secondary to Malignancy

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Repetitive Transcranial Magnetic Stimulation in Visceral Pain Secondary to Malignancy

Brief Summary: The purpose of this study is to assess the efficacy of rTMS over primary motor cortex in patients suffering from malignant visceral pain. Thirty four patients were included in the study. They are divided randomly into 2 groups using closed envelop as real rTMS group and sham group. Real rTMS over the hand area of motor cortex (20 Hz, 10 trains with inter train interval 30 second with total pulses 2000, intensity 80% of motor threshold) every day for ten consecutive days (5 days/week) and the coil elevated and angled away from the head as sham stimulation. Patients were evaluated by verbal descriptor scale (VDS), visual analog scale (VAS), and Hamilton rating scale for depression (HAM-D) at the baseline, after 1st, 5th, 10th session, 15 day and 1 month after end of sessions. Serum human dynorphin (Dyn) level was measured at baseline, 5th and 10th session.

Detailed Summary:
Sponsor: Assiut University

Current Primary Outcome: Visceral pain improvement [ Time Frame: one month ]

Reduction of visceral pain in patients with malignancy measured by VAS, VDS.


Original Primary Outcome: Same as current

Current Secondary Outcome: Reduction of depression manifestation [ Time Frame: one month ]

Measurement of depression by using (HAM-D) scale.


Original Secondary Outcome: Same as current

Information By: Assiut University

Dates:
Date Received: March 19, 2014
Date Started: January 2010
Date Completion:
Last Updated: March 19, 2014
Last Verified: March 2014