Clinical Trial: Effects of Intracoronary Prourokinase on the Coronary Flow During Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: A Randomized, Parallel-controlled, Multi-center Study of the Effects of Intracoronary Recombinant HUman Prourokinase or TIrofiban on the Coronary Flow During Primary PCI for the Acute Myocardial Infar

Brief Summary: The purpose of this study is to determine whether intracoronary selective thrombolysis are more effective than tirofiban on the coronary flow during primary percutaneous coronary intervention for the acute myocardial infarction.

Detailed Summary:
Sponsor: Fudan University

Current Primary Outcome: Coronary flow using corrected Thrombolysis In Myocardial Infarction Frame Count (cTFC) [ Time Frame: At the end of Percutaneous Coronary Intervention procedure ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • ST segment resolution in ECG [ Time Frame: 3 hours post PCI procedure ]
  • peak troponin T level [ Time Frame: in the 7 days post PCI procedure ]
  • plasma N terminal-proBNP levels [ Time Frame: 1 and 30 days post PCI procedure ]
  • infarction area confirmed by SPECT [ Time Frame: 30 days post PCI ]
  • incidence of major adverse cardiac events (MACE) defined as the composite of death, myocardial infarction and target vessel revascularization [ Time Frame: 30 days post PCI ]


Original Secondary Outcome: Same as current

Information By: Fudan University

Dates:
Date Received: May 3, 2014
Date Started: November 2015
Date Completion: September 2017
Last Updated: August 8, 2016
Last Verified: August 2016