Clinical Trial: Genetic Basis of Melanocytic Nevi

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: Genetic Basis of Melanocytic Nevi

Brief Summary:

The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens.

Herein, we plan to isolate DNA from de-identified skin biopsy specimens and blood samples:

  1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis.
  2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.

Detailed Summary:
Sponsor: University of California, Davis

Current Primary Outcome: Genetic Analysis [ Time Frame: Feb 2017 - December 2018 ]

Will be performing genetic analysis of Nevi


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of California, Davis

Dates:
Date Received: February 13, 2017
Date Started: February 13, 2017
Date Completion: April 1, 2019
Last Updated: February 13, 2017
Last Verified: February 2017