Clinical Trial: Optical Clearing of the Skin in Conjunction With Laser Treatments

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Optical Clearing of the Skin in Conjunction With Laser Treatments

Brief Summary: The research hypothesis is that topical application of a mixture of pre-polymers of polypropylene glycol and polyethylene glycol (an optical clearing agent) will reduce skin light scattering, increasing the amount of light reaching the target for diagnostic as well as therapeutic purposes.

Detailed Summary:

The researchers expect that application of the optical clearing agent for treatment of benign vascular lesions, tattoos, nevus of Ota, hypertrichosis, scars, acne and sebaceous hyperplasia will result in

  1. decreased reflectance of the predominant color from the surface of skin (decreased red light scattering in case of benign vascular lesions, etc) as compared to the control group.
  2. greater Optical Coherence Tomography a non-invasive light based imaging method imaging depth as compared to the control group.
  3. greater improvement in the treatment outcome (decrease in the erythema index following laser treatment of vascular lesions as compared to the laser alone group; improved lightening of the tattoo or nevus of Ota as compared to the laser treatment alone group; significant decrease in hair re-growth as compared to laser treatment alone in patients seeking hair removal; greater improvement of scars, acne and sebaceous hyperplasia).

Sponsor: University of California, Irvine

Current Primary Outcome: Outcome measure is to evaluate the optical clearing effects of the combination mixture of pre-polymers of polypropylene glycol and polyethylene glycol. [ Time Frame: 8 weeks ]

Original Primary Outcome: Outcome Measure are to evaluate the optical clearing effects of the combination mixture of pre-polymers of polypropylene glycol and polyethylene glycol. [ Time Frame: 8 weeks ]

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of California, Irvine

Dates:
Date Received: December 18, 2007
Date Started: March 2004
Date Completion:
Last Updated: February 8, 2017
Last Verified: February 2017