Clinical Trial: Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Multicenter Prospective Analysis of Treatment Outcome in Patients With Large Acoustic Neuromas

Brief Summary: The investigators study is to investigate safety and efficacy of performing a planned incomplete removal of large acoustic neuroma tumors to decrease surgical morbidity and yet avoid tumor recurrence by post-operative radiation therapy.

Detailed Summary: The current standard treatment of a large tumor of the balance nerve (acoustic neuroma or vestibular schwannoma) is surgical resection. Complete removal of such tumor is associated with significant risks of hearing loss and facial paralysis whereas incomplete removal of the tumor is associated with significant risks of regrowth. Stereotactic radiation is a well accepted therapy aiming at stopping the growth of smaller acoustic neuromas before their sizes become large enough to cause problems. The purpose of our study is to determine whether the combination of subtotal resection followed by stereotactic radiation of the remnant can control large acoustic neuromas without the significant risks associated with complete resection.
Sponsor: Stanford University

Current Primary Outcome: Need for stereotactic radiation therapy should tumor remnant grow on annual MRI's [ Time Frame: 10 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Facial nerve function measured on House-Brackmann scale [ Time Frame: 10 y ]

Original Secondary Outcome: Same as current

Information By: Stanford University

Dates:
Date Received: March 10, 2010
Date Started: March 2005
Date Completion: March 2025
Last Updated: April 24, 2017
Last Verified: April 2017