Clinical Trial: Postoperative Neuroinflammation and Cognitive Dysfunction After Abdominal Surgery

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title:

Brief Summary: The main purpose of this study is to assess the induction of neuroinflammation in brain regions of interest for learning and memory in adult patients undergoing urological surgery under general anesthesia

Detailed Summary: The investigators aim to study immune cell activation as a biomarker for neuroinflammation using the cell specific [11C]PBR28 probe as detected by PET imaging techniques.
Sponsor: Karolinska University Hospital

Current Primary Outcome: Binding of the PET probe [11C]PBR28 [ Time Frame: Preoperatively, once at postoperative day 2-5 and after 3 month ]

PET imaging of brain regions of relevance for memory and learning will be compared between the pre- and postoperative states.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Cognitive testing [ Time Frame: Preoperatively and after 3 month ]
    Postoperative cognitive test battery according to the ISPOCD protocol, see Moller JT et al, Lancet 1998.
  • Inflammatory biomarkers [ Time Frame: Preoperatively, once at postoperative day 2-5 and after 3 month, i.e. at the same time as the PET investigation ]
    Inflammatory biomarkers and genetic analysis of inflammatory biomarkers in blood.


Original Secondary Outcome: Same as current

Information By: Karolinska University Hospital

Dates:
Date Received: June 13, 2013
Date Started: June 2013
Date Completion:
Last Updated: January 10, 2017
Last Verified: January 2017