Clinical Trial: High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Treatment Protocol for High-Risk PNET Brain Tumors in Children With Surgery, Sequential Chemotherapy, Conventional and High-Dose With Peripheral Blood Stem Cell Transplant

Brief Summary: The purpose of this study is to evaluate the efficacy of the combination of surgery, conventional chemotherapy, sequential high-dose chemotherapy with peripheral blood stem cell transplantation and reduced dose radiation therapy in high-risk PNET brain tumors.

Detailed Summary:
Sponsor: Gustave Roussy, Cancer Campus, Grand Paris

Current Primary Outcome:

  • Response of medulloblastoma metastases to the chemotherapy regimen in children less than 5 years of age
  • Progression-free survival of children less than 10 years of age with brain PNET


Original Primary Outcome:

  • Response of medulloblastoma metastases to the chemotherapy regimen in children less than 5 years of age
  • Progression-free survival of brain PNET in children less than 10 years of age


Current Secondary Outcome:

  • Progression-free survival of children less than 5 years of age with metastatic medulloblastoma
  • Toxicity
  • Long term sequelae


Original Secondary Outcome:

  • Progression-free-survival of metastatic medulloblastoma in children less than 5 years
  • Toxicity
  • Long term sequelae


Information By: Gustave Roussy, Cancer Campus, Grand Paris

Dates:
Date Received: September 9, 2005
Date Started: July 2002
Date Completion:
Last Updated: September 17, 2007
Last Verified: September 2006