Clinical Trial: High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Treatment Protocol for High-Risk PNET Brain Tumors in Children With Surgery, Sequential Chemotherapy, Conventional and High-Dose With Peripheral Blood Stem Cell Transplant
Brief Summary: The purpose of this study is to evaluate the efficacy of the combination of surgery, conventional chemotherapy, sequential high-dose chemotherapy with peripheral blood stem cell transplantation and reduced dose radiation therapy in high-risk PNET brain tumors.
Detailed Summary:
Sponsor: Gustave Roussy, Cancer Campus, Grand Paris
Current Primary Outcome:
- Response of medulloblastoma metastases to the chemotherapy regimen in children less than 5 years of age
- Progression-free survival of children less than 10 years of age with brain PNET
Original Primary Outcome:
- Response of medulloblastoma metastases to the chemotherapy regimen in children less than 5 years of age
- Progression-free survival of brain PNET in children less than 10 years of age
Current Secondary Outcome:
- Progression-free survival of children less than 5 years of age with metastatic medulloblastoma
- Toxicity
- Long term sequelae
Original Secondary Outcome:
- Progression-free-survival of metastatic medulloblastoma in children less than 5 years
- Toxicity
- Long term sequelae
Information By: Gustave Roussy, Cancer Campus, Grand Paris
Dates:
Date Received: September 9, 2005
Date Started: July 2002
Date Completion:
Last Updated: September 17, 2007
Last Verified: September 2006