Clinical Trial: Tysabri Effects on Cognition and Neurodegeneration in Multiple Sclerosis
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Tysabri Effects on Cognition and Neurodegeneration in Multiple Sclerosis
Brief Summary: The long-term objective is to further establish the role of Tysabri in preventing neurological degeneration in multiple sclerosis (MS) and to establish powerful and efficient new markers for neurological degeneration in MS. The study intends to correlate cognition with two instruments and their measurements-MRI and OCT (optical coherence tomography).
Detailed Summary:
The specific aims are:
- To determine the effects of Tysabri on cognition (memory, thought processes, etc.)
- To determine the effects of Tysabri on specific MRI markers for cognitive dysfunction
- To determine the effects of Tysabri on retinal nerve fiber layer thickness (RNFL) using optical coherence tomography (OCT), a special instrument used in ophthalmology
Sponsor: University of Chicago
Current Primary Outcome: specific MRI parameters and RNFL (retinal nerve fiber layer) thickness in OCT optical coherence tomography in correlation with cognition measurements [ Time Frame: 2 years ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: University of Chicago
Dates:
Date Received: February 17, 2010
Date Started: April 2010
Date Completion:
Last Updated: July 27, 2016
Last Verified: July 2016
