Clinical Trial: Orange Juice Consumption and Cognitive Function

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Chronic Orange Juice Consumption on Cognitive Function in Healthy Older Adults

Brief Summary: This study is investigating the effect of 8 weeks of orange juice supplementation on executive function in healthy older adults. The study is a controled, double-blind, crossover trial and involves a 8 week supplementation with a high flavonone orange juice and a carbohydrate-matched control. Volunteers consume 500ml of either the test juice or the control juice per day for an 8 week period. There is then an 8 week washout period before subjects proceed to the other arm of the study. Subjects are randomly assigned to either arm at the beginning of the study. Measures of cognitive function will be administered pre and post both test and control interventions. Blood pressure will also be measured and blood and urine samples will be collected to assess absorption of from the juice. A sub-sample of volunteers will undergo MRI imaging pre- and post intervention to acquire cerebral blow flow information.

Detailed Summary:
Sponsor: University of Reading

Current Primary Outcome: Executive function - Attention [ Time Frame: change in attention from baseline and 8 weeks ]

Assessment by human cognitive test battery delivered by computer and human operator. Assessments will be carried out at baseline and at the end of each intervention arm.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Plasma flavanones [ Time Frame: change from baseline to 8 weeks ]
    By High performance liquid chromatography
  • Blood pressure [ Time Frame: change from baseline to 8 weeks ]
    Blood pressure measurement


Original Secondary Outcome: Same as current

Information By: University of Reading

Dates:
Date Received: March 9, 2011
Date Started: September 2010
Date Completion:
Last Updated: November 22, 2011
Last Verified: November 2011