Clinical Trial: Secondary Cancer Risk After Radiation Therapy for Rectal Cancer

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Estimation of Second Cancer Risk in Patients Planned With Different Radiotherapy Regimes for Rectal Cancer - A Planning Study and Model-based Analysis

Brief Summary: Retrospective study comparing dose distribution of 3D conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT) to estimate secondary cancer risk for patients having had radiation therapy for rectal cancer. Twenty-five patients are included in this study. Planning CT scans are used for comparison of dose distribution and calculation of second cancer risk.

Detailed Summary: A model-based Analysis calculating the organ-specific excess lifetime attributable risk using the planning CT data sets of 25 patients to estimate second cancer risk for patients after radiotherapy for rectal cancer comparing conventional 3DCRT with VAMT techniques.
Sponsor: Kantonsspital Graubuenden

Current Primary Outcome: Calculation of the organ-specific excess lifetime attributable risk (LAR) (%) [ Time Frame: 60 years (model-based calculation) ]

LAR is calculated for variable Ages at exposure


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Kantonsspital Graubuenden

Dates:
Date Received: October 4, 2015
Date Started: August 2015
Date Completion:
Last Updated: December 11, 2016
Last Verified: December 2016