Clinical Trial: Nausea in Patients Receiving Hydromorphone vs Oxycodone After Total Hip Replacement Surgery

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: Nausea in Patients Receiving Hydromorphone vs Oxycodone After Total Hip Replacement Surgery

Brief Summary: The study aims to compare the incidence of side effects caused by Oxycodone and Hydromorphone.

Detailed Summary: Nausea and vomiting in the post-operative period is considered strongly undesirable by patients and has adverse effects on recovery from outpatient procedures, contributing significantly to delays in discharge from recovery. A know major contributor to the occurrence of post-operative nausea and vomiting is the use of opiate medications which are the cornerstone of post-operative pain management. The investigators hypothesize that the occurrence of this side-effect is different between patients prescribed oxycodone and those receiving hydromorphone for acute pain management after total hip replacement surgery. This investigation is a randomized, double-blind, head-to-head comparison to equipotent administration of oxycodone vs. hydromorphone to determine whether such a difference exists.
Sponsor: University Health Network, Toronto

Current Primary Outcome: The occurrence of postoperative nausea [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of 72 hours ]

The incidence and severity of nausea will be recorded twice daily up to 72 hours post-operatively


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Daily pain scores [ Time Frame: 72 hours after surgery ]
    Pain scores (0-10) will be recorded twice daily until 72 hours post-operatively
  • Incidence of opioid related itching [ Time Frame: 72 hours after surgery ]
    The presence or absence of the opioid related side effects will be recorded twice daily until 72 hours post-operatively
  • Incidence of delirium [ Time Frame: 72 hours after surgery ]
    The presence of delirium will be recorded until 72 hours post-operatively
  • Cumulative in-hospital opioid consumption [ Time Frame: 72 hours after surgery ]
    Total in-hospital opioid consumption in morphine equivalent doses will be calculated for the first 72 hours post-operatively
  • Use of anti-nausea medications [ Time Frame: 72 hours after surgery ]
    The number of administrations and doses of anti-nausea medications will be evaluated until 72 hours post-operatively
  • Cumulative drug costs per patient [ Time Frame: 72 hours after surgery ]
    The cumulative drug cost based on all anti-nausea and analgesic medications administered will be calculated for the first 72 hours post-operatively
  • Post-operative admission duration [ Time Frame: Total admission duration, an expected average of 72 hours ]
    The number of post-operative days required for admission will be assessed. Duration is to be an expected average of 72 hours


Original Secondary Outcome: Same as current

Information By: University Health Network, Toronto

Dates:
Date Received: February 11, 2013
Date Started: August 2012
Date Completion: June 2017
Last Updated: October 27, 2016
Last Verified: October 2016