Clinical Trial: Benefit of Changing Chemoradiotherapy Sequence and Modifying Radiotherapy Schedule for Advanced Nasopharyngeal Cancer
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Randomized Trial to Evaluate the Therapeutic Gain by Changing the Chemoradiotherapy From Concurrent-adjuvant to Induction-concurrent Sequence, and the Radiotherapy From Conventional to Accelerated Fra
Brief Summary:
The objectives of this clinical study are threefold:
- To compare the benefits in cancer control and survival obtained from adding induction-concurrent chemotherapy to radiation with those from adding concurrent-adjuvant chemotherapy to radiation.
- To test whether replacing fluorouracil with Xeloda in combining with cisplatin (PF or PX, respectively) in the chemotherapy plan will maintain or improve further the chemotherapy benefits while reducing the duration of hospital stay.
- To see if accelerated fractionation radiotherapy can improve the outcome of patients as compared with conventional fractionation radiotherapy.
Detailed Summary:
Sponsor: Hospital Authority, Hong Kong
Current Primary Outcome:
- Progression-free survival [ Time Frame: 5-year ]
- Overall Survival [ Time Frame: 5-year ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Overall / Locoregional / Distant Failure Free Rate [ Time Frame: 5-year ]
- Chemotherapy and RT toxicity [ Time Frame: within 90 day from commencement of RT ]
- Late Toxicity [ Time Frame: 5-year ]
Original Secondary Outcome: Same as current
Information By: Hospital Authority, Hong Kong
Dates:
Date Received: December 18, 2007
Date Started: September 2006
Date Completion: August 2013
Last Updated: August 21, 2013
Last Verified: August 2013
