Clinical Trial: Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients Pre and Post Concurrent Chemo-radiation Therapy

Brief Summary: The purpose of this study is to evaluate whether dietary nitrate supplementation could improve the salivary flow for nasopharyngeal carcinoma patients receiving concurrent chemo-radiation therapy.

Detailed Summary: Thirty patients diagnosed as nasopharyngeal carcinoma will be recruited. Nitrate supplement(Sodium nitrate: 0.5 mmol/kgbodyweight,bid) or placebo(sodium chloride: 0.5 mmol/kgbodyweight,bid) will be provided to the patients from 7 days before radiotherapy to one month after the finish of radiotherapy . The salivary flow and plasma nitrate levels will be determined before the course of nitrate supplementation and radiotherapy,before the course of radiotherapy,post the course of radiotherapy immediately and one month after the finish of radiotherapy.
Sponsor: Capital Medical University

Current Primary Outcome: Change of salivary flow [ Time Frame: one day before the course of nitrate supplementation and radiotherapy,one day before the course of radiotherapy,one day post the course of radiotherapy and one month after the finish of radiotherapy ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Chang of plasm nitrate level [ Time Frame: one day before the course of nitrate supplementation and radiotherapy,one day before the course of radiotherapy,one day post the course of radiotherapy and one month after the finish of radiotherapy ]

Original Secondary Outcome: Same as current

Information By: Capital Medical University

Dates:
Date Received: July 23, 2016
Date Started: August 2016
Date Completion: December 2018
Last Updated: July 31, 2016
Last Verified: July 2016