Clinical Trial: Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus During General Anesthesia Induction Period

Brief Summary: By observing the difference of plasma homovanillic acid concentrations and brain electrical consciousness monitoring Narcotrend index, study the possible mechanism of influencing Etomidate induced myoclonus with Dexmedetomidine pretreatment during general anesthesia induction period.

Detailed Summary:
Sponsor: Tang-Du Hospital

Current Primary Outcome:

  • myoclonus level [ Time Frame: when myoclonus occurs after emulsion injection is completed，assessed up to 5 minutes ]
    • Level 0 ：no myoclonus happened;
    • Level 1 ：mild, tiny movement, one part of the body such as a finger or shoulder movement;
    • Level 2 ：moderate ,2 pieces of different muscle or slight movement of the muscle groups, such as face or legs;
    • Level 3 ：severely, 2 pieces or more muscle contracture intensity, such as fast outreach of limbs
  • Plasma homovanillic acid concentration（PHVA） [ Time Frame: Measured when myoclonus occurs after emulsion injection is completed，assessed up to 5 minutes; if myoclonus does not appear,measured at 5 minutes after emulsion injection is completed. ]


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Ramsay sedation score [ Time Frame: 1 min after entering the operating room; 1 min after dexmedetomidine injection is completed; 1 min after emulsion injection is completed;5 minutes after emulsion injection is completed； ]
  • Narcotrend index [ Time Frame: 1 min after entering the operating room; 1 min after dexmedetomidine injection is completed; 1 min after emulsion injection is completed;5 minutes after emulsion injection is completed； ]


Original Secondary Outcome: Same as current

Information By: Tang-Du Hospital

Dates:
Date Received: August 3, 2015
Date Started: September 2015
Date Completion: September 2016
Last Updated: August 7, 2015
Last Verified: August 2015