Clinical Trial: CMR in Patients With Myocarditis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Value of CMR Including T1 Mapping in Patients With Acute Myocarditis

Brief Summary: To evaluate the additive values of T1 mapping in patients with acute myocarditis.

Detailed Summary:

Cardiac magnetic resonance (CMR) is an established non-invasive diagnostic tool for acute and chronic myocarditis. Established CMR criteria for diagnosing myocarditis are edema on black-blood T2-weighted imaging, relative contrast enhancement seen on T1-weighted imaging for assessment of hyperemia, and late contrast-agent enhancement seen with inversion recovery late enhancement technique for visualization of myocardial fibrosis.

Recently, tissue characterization based on calculation of myocardial T1 relaxation time (T1 mapping) as well as T1-derived extracellular volume fraction has become available. Recently, reference values for myocardial T1 relaxation times at 3T for healthy volunteers were published for CMR. However, to date no comprehensive data for multiparametric CMR in patients with suspected myocarditis at 3 Tesla is available. Therefore, the purpose of this prospective study was to evaluate the diagnostic value of CMR at 3T in patients with suspected acute myocarditis using a multiparametric CMR approach including T1 mapping as novel tool for tissue characterization.

CMR will be performed within 7 days after hospital admission for "suspected acute myocarditis".


Sponsor: University Hospital, Bonn

Current Primary Outcome: T1 relaxation times [ Time Frame: time of CMR, CMR will be performed within 7 days after hospital admission for "suspected acute myocardtitis". ]

quantification of T1 relaxation times


Original Primary Outcome: Same as current

Current Secondary Outcome: Extracellular volume (ECV) [ Time Frame: time of CMR, CMR will be performed within 7 days after hospital admission for "suspected acute myocardtitis". ]

calculation of extracellular volume based on T1 relaxation time


Original Secondary Outcome: Same as current

Information By: University Hospital, Bonn

Dates:
Date Received: October 4, 2013
Date Started: September 2013
Date Completion:
Last Updated: December 9, 2015
Last Verified: December 2015