Clinical Trial: Cardiac Magnetic Resonance in Acute Myocarditis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Cardiac Magnetic Resonance in Acute Myocarditis

Brief Summary: Cardiac magnetic resonance (MR) is an established noninvasive diagnostic tool for detection of acute myocarditis. Diagnosis of myocarditis at 1.5T is currently made with the help of the Lake Louise Criteria (two of three criteria have to be positive in order to establish the diagnosis). Although these criteria are accepted and widely used in clinical routine, several disadvantages exist. Newer parameters like myocardial T1 and T2 mapping, extracellular volume fraction (ECV) and myocardial strain analysis have the potential to complement or even replace some of the Lake Louise Criteria and further enhance the diagnostic performance of cardiac MR in patients suspected of having acute myocarditis. The aim of our study is to evaluate the diagnostic performance of a comprehensive cardiac MR protocol in patients with acute myocarditis.

Detailed Summary:
Sponsor: University Hospital, Bonn

Current Primary Outcome:

• Myocardial T1 relaxation time [ Time Frame: Measurement will be performed within 2 weeks after MRI scan. ]
  Changes in myocardial T1 relaxation time is of interest in patients with acute myocarditis. T1 relaxation times will be directly obtained from the T1 maps through ROI analysis. T1 maps will be analyzed using a segmental approach. T1 relaxation times are given in [ms].
• Myocardial T2 relaxation time [ Time Frame: Measurement will be performed within 2 weeks after MRI scan. ]
  Changes in myocardial T2 relaxation time is of interest in patients with acute myocarditis. T2 relaxation times will be directly obtained from T2 maps through ROI analysis. T2 maps will be analyzed using a segmental approach. T2 relaxation times are given in [ms].
• Myocardial ECV measurements [ Time Frame: Measurement will be performed within 2 weeks after MRI scan. ]

  Changes in myocardial ECV parameters is of interest in patients with acute myocarditis. Hematocrit corrected ECV will be calculated using pre- and post-contrast T1 values for myocardium and blood pool using following formula:

  ECV= (1⁄T1 "myocardium post contrast"-1⁄T1 "myocadium pre contrast")/(1⁄T1 "blood post contrast"-1⁄ T1 "blood pre contrast") x (1-hematocrit).

  ECV is given in percentage.

• Myocardial strain analysis (focussed on longitudinal strain) [ Time Frame: Measurement will be performed within 2 weeks after MRI scan.
  
  

  Original Primary Outcome: Same as current
  
  

  Current Secondary Outcome:
  
  

  Original Secondary Outcome:
  
  Information By: University Hospital, Bonn
  

  Dates:
  Date Received: November 13, 2014
  Date Started: March 2014
  Date Completion:
  Last Updated: December 9, 2015
  Last Verified: December 2015