Clinical Trial: The Protective Effects Of Treatment With Hyperbaric Oxygen Prior To Bypass Heart Surgery

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Effects of Hyperbaric Oxygen Preconditioning On Cardiovascular Protection & Ischemic Reperfusion Injury

Brief Summary: The purpose of this study was to determine if treating patients who have coronary heart disease with hyperbaric oxygen (HBO) prior to coronary artery bypass graft (CABG) surgery reduces injury to the heart and vascular system during and after surgery. Furthermore, this study also aims to identify some of the post CABG clinical effects of HBO treatment prior to CABG.

Detailed Summary:
Sponsor: Hull and East Yorkshire Hospitals NHS Trust

Current Primary Outcome:

  • Myocardial Hsp72 protein [ Time Frame: Intra-operative (During CABG) ]
  • Myocardial eNOS protein [ Time Frame: Intra-Operative (During CABG) ]
  • Serum Troponin-T [ Time Frame: Peri-operative ]
  • Serum soluble ICAM-1 [ Time Frame: Peri-operative ]
  • Serum soluble PSGL-1 [ Time Frame: Peri-operative ]
  • Serum soluble P-Selectin [ Time Frame: Peri-operative ]
  • Serum soluble E-Selectin [ Time Frame: Peri-operative ]


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • All cardiovascular haemodynamic parameters as measured by a pulmonary artery catheter [ Time Frame: Peri-operative ]
  • Duration of mechanical ventilation [ Time Frame: Post Operative ]
  • Duration of endotracheal intubation [ Time Frame: post operative ]
  • Length of stay in ICU [ Time Frame: Post-operative ]
  • Blood loss [ Time Frame: Post operative ]
  • Inotrope usage [ Time Frame: Post operative ]
  • Atrial Fibrillation [ Time Frame: Post operative ]
  • Low cardiac output status [ Time Frame: Post operative ]
  • Pulmonary complications [ Time Frame: Post operative ]
  • Renal Complications [ Time Frame: Post operative ]
  • Cerebrovascular complications [ Time Frame: Post operative ]
  • Gastrointestinal complications [ Time Frame: Post operative ]
  • Wound complications [ Time Frame: Post operative ]
  • Cost of ICU stay [ Time Frame: Post operative ]


Original Secondary Outcome: Same as current

Information By: Hull and East Yorkshire Hospitals NHS Trust

Dates:
Date Received: February 14, 2008
Date Started: January 2005
Date Completion:
Last Updated: February 22, 2008
Last Verified: January 2008