Clinical Trial: Delayed Postconditioning

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Delayed Angioplasty Postconditioning in STEMI Patients

Brief Summary:

The investigators previously reported that angioplasty postconditioning reduces infarct size (cardiac enzyme release) in STEMI patients with a fully occluded coronary artery at hospital admission. Animal studies have suggested that the time window for applying brief episodes of ischemia and reperfusion aimed at triggering postconditioning's protection is very narrow, i.e. does not expand beyond 1 minute after reflow. We sought to address whether this window might be larger in humans, i.e. whether STEMI patients might be protected several minutes after undergoing spontaneous reperfusion before admission coronary angiography.

Therefore, STEMI patients (onset of chest pain less than 12 hours) with a TIMI flow grade > 1 were eligible for that study. Angioplasty postconditioning was completed as already published and infarct size was assessed by measuring cardiac enzymes release.

Detailed Summary:
Sponsor: Hospices Civils de Lyon

Current Primary Outcome: Size of the infarct [ Time Frame: Day 5 post reperfusion ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Contractile functional recovery [ Time Frame: 6 months after reperfusion ]

Original Secondary Outcome: Same as current

Information By: Hospices Civils de Lyon

Dates:
Date Received: November 30, 2011
Date Started: July 2009
Date Completion:
Last Updated: July 26, 2013
Last Verified: July 2013