Clinical Trial: Sevoflurane and Isoflurane - During Cardiopulmonary Bypass With the MECC System (Minimized Extracorporeal Circuit)
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Sevoflurane and Isoflurane - Cardioprotective Effects, Hemodynamic Stability and Pharmacokinetics During Cardiopulmonary Bypass With the MECC System
Brief Summary:
The use of volatile anesthetics in cardiac anesthesia is very common, because of their cardioprotective effects and their ability to ensure a sufficient depth of anesthesia. In line with the development of fast track concepts in cardiac anesthesia, volatile anesthetics are widely used to avoid a delayed recovery from cardiac surgery and anesthesia. Volatile anesthetics are delivered from calibrated vaporizers in the anesthesia machine or the cardiopulmonary bypass machine (during extracorporeal circulation).
Isoflurane and Sevoflurane are the most commonly used volatile anesthetics in patients undergoing cardiopulmonary bypass (CPB). The vaporizer of the anesthetics is on the cardiopulmonary bypass machine and the volatile agent is blended with air and oxygen. Until now, the pharmacokinetics of halothane, enflurane, isoflurane and desflurane during CPB have been described.
Sevoflurane might be of advantage because of additional myocardial protective effects during cardiac anesthesia and cardiopulmonary bypass. However, the pharmacokinetics of sevoflurane during CPB have not been investigated so far, although its being used at many hospitals.
The investigators will conduct a randomized prospective study with either sevoflurane or isoflurane during cardiopulmonary bypass surgery. The study will help to answer the questions about the possible cardioprotective effects of the widely used volatile anesthetics and the hemodynamic stability during cardiopulmonary bypass. Knowing the pharmacokinetics of these drugs allows the anesthesiologist to titrate the volatile anesthetics more precise.
The investigators hypothesizes that the maximal postoperative increase in troponin T will be smaller in the sevoflurane group than in the isoflu
Detailed Summary:
Endpoints Primary Endpoint: Troponin
The study will compare the maximum postoperative troponin levels in the isoflurane and sevoflurane groups as a direct quantitative marker of damaged myocardial cells. Maximum troponin levels should be reached within the first 24 hours after surgery.
Secondary Endpoints:
A) Hemodynamic stability during on-pump
The investigators will compare the hemodynamic stability during CPB between the isoflurane and sevoflurane group. Therefore the total dosage of noradrenaline used during the surgery will be measured.
B) Washin and Washout Kinetic
Kinetics of washin and washout of sevoflurane and isoflurane during CPB will be investigated and described.
C) Extubation time and length of stay in the intensive care and in hospital
Time to extubation and the length of stay in intensive care unit and in hospital will be documented.
D) Mortality after 30 days
The mortality after 30 days will also be monitored. If the patient is no more in the hospital a phone call will be made.
Sponsor: University Hospital, Basel, Switzerland
Current Primary Outcome: postoperative maximum Troponin levels [ Time Frame: 24 hours ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Hemodynamic stability during on-pump [ Time Frame: 2 hours ]
Original Secondary Outcome: Same as current
Information By: University Hospital, Basel, Switzerland
Dates:
Date Received: May 2, 2012
Date Started: July 2012
Date Completion:
Last Updated: January 28, 2014
Last Verified: January 2014
