Clinical Trial: The Optimization of Mycoplasm Pneumonia Antibiotic Therapy

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Optimization of Mycoplasm Pneumonia Antibiotic Therapy: Multi-centre, Prospective, Randomized Controlled Study

Brief Summary: Mycoplasma pneumoniae, an important pathogen of community acquired pneumonia,are becoming more and more resistant to macrolide. The study aim is to optimize anti-infection therapy.

Detailed Summary: Mycoplasma pneumoniae was one of important atypical pathogens of community acquired pneumonia. As lack of cell wall, β-lactam medicines were invalid, however, macrolides, tetracyclines and quinolones were effective. But from 2001, many countries reported macrolide- resistant Mycoplasma pneumoniae. Typically, erythromycin was first-line antibiotic medicine. With the resistance increasing, Mycoplasm pneumonia treatment will become more and more difficult. Thus, optimization of Mycoplasm pneumonia antibiotic therapy is very important.
Sponsor: Capital Medical University

Current Primary Outcome:

  • Time to resolution of fever (defined as the period from start of study-drug to relief of fever) [ Time Frame: one month ]
    usually duration of fever is about one to two weeks
  • Time to resolution of fever (defined as the period from onset to relief of fever) [ Time Frame: one month ]
    usually duration of fever is about one to two weeks


Original Primary Outcome:

  • Time to resolution of fever (defined as the period from start of study-drug to relief of fever) [ Time Frame: one year ]
  • Time to resolution of fever (defined as the period from onset to relief of fever) [ Time Frame: one year ]


Current Secondary Outcome:

  • Time to resolution of respiratory symptoms(defined as the period from start of study-drug to relief of symptoms) [ Time Frame: one year ]
  • Time to resolution of respiratory symptoms(defined as the period from onset to relief of symptoms) [ Time Frame: one year ]
  • Proportion of antibiotics change [ Time Frame: one year ]
  • Duration of antibiotics [ Time Frame: one year ]
  • Proportion of resolution of fever after antibiotics therapy for 24 hours [ Time Frame: one year ]
  • Proportion of resolution of fever after antibiotics therapy for 72 hours [ Time Frame: one year ]
  • Antibiotic-related adverse reaction [ Time Frame: one year ]


Original Secondary Outcome: Same as current

Information By: Capital Medical University

Dates:
Date Received: December 13, 2010
Date Started: October 2010
Date Completion:
Last Updated: July 25, 2015
Last Verified: July 2015