Clinical Trial: Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title:

Brief Summary: Genital ureaplasmas (Ureaplasma urealyticum and Ureaplasma parvum) and genital mycoplasmas (Mycoplasma hominis and Mycoplasma genitalium) are natural inhabitants of the male urethra contaminating the semen during ejaculation. However, these microorganisms, especially Ureaplasma urealyticum (Uu) and Mycoplasma hominis (Mh), are potentially pathogenic species playing an etiologic role in both genital infections and male infertility. Despite there are many consentaneous opinions about its relationship with infertility, its correlation with sperm regular parameters is still controversially. Sperm DNA damage can negatively influence fertilization rate, embryo cleavage rate, implantation rate, pregnancy and live birth rate, and is a novel indicator for intrauterine insemination (IUI) pregnancy rate and IVF or ICSI pregnancy loss rate. Until now, there were fewer clinical researches about the relationship among Uu and/or Mh infection, sperm DNA damage, and the IUI pregnancy rate. Thus, the investigators conduct this prospective study to investigate the relationship among them.

Detailed Summary:
Sponsor: Feng Pan

Current Primary Outcome: pregnancy rate [ Time Frame: up to 3 monthes after IUI ]

Original Primary Outcome: Same as current

Current Secondary Outcome: sperm DNA fragmentation index (DFI) [ Time Frame: one month before IUI ]

Original Secondary Outcome: Same as current

Information By: Nanjing Medical University

Dates:
Date Received: March 9, 2012
Date Started: September 2011
Date Completion: December 2013
Last Updated: April 8, 2013
Last Verified: April 2013