Clinical Trial: Diagnostic Accuracy of Nontuberculous Mycobacterial Lung Disease Based on Chest CT

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Diagnostic Accuracy and Inter-rater Agreement of Chest Computed Tomography in the Diagnosis of Nontuberculous Mycobacterial Lung Disease

Brief Summary: The aim of this study was to elucidate the accuracy and inter-rater agreement of diagnosis of nontuberculous mycobacterial lung disease based on chest computed tomography findings.

Detailed Summary: To elucidate the accuracy and inter-rater agreement of diagnosis of nontuberculous mycobacterial lung disease based on chest CT, two pulmonologists and two chest radiologists were requested to interpret chest CT of patients nontuberculous mycobacterial lung disease satisfying diagnostic criteria of American Thoracic Society as well as British Thoracic Society, or pulmonary tuberculosis. Two pulmonologists and two chest radiologists > 10 years of clinical experiences at a tertiary referral hospital participated as raters in this study. They were blinded to the any clinical information of the patients including the specific diagnosis, except age and sex. The interpretations of four raters were analyzed and compared.
Sponsor: Seoul National University Hospital

Current Primary Outcome: Sensitivity for the diagnosis of nontuberculous mycobacterial lung disease [ Time Frame: baseline ]

Percentage of cases diagnosed as nontuberculous mycobacterial lung disease by four raters out of confirmed cases with nontuberculous mycobacterial lung disease


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Inter-rater correlation (kappa value) for the diagnosis of nontuberculous mycobacterial lung disease [ Time Frame: baseline ]
    Inter-rater correlation between four raters
  • Specificity for the diagnosis nontuberculous mycobacterial lung disease [ Time Frame: baseline ]
    Percentage of cases diagnosed as other than nontuberculous mycobacterial lung disease by four raters out of confirmed cases with other than nontuberculous mycobacterial lung disease


Original Secondary Outcome: Same as current

Information By: Seoul National University Hospital

Dates:
Date Received: December 27, 2014
Date Started: December 2014
Date Completion:
Last Updated: April 18, 2016
Last Verified: April 2016