Clinical Trial: Bedrest, Feeding Pattern, and Insulin Sensitivity

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Impact of Continuous Versus Intermittent Feeding on Changes in Insulin Sensitivity During Bed-rest

Brief Summary: In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.

Detailed Summary: In the present study, the investigators will assess the impact of two different feeding patterns on insulin sensitivity and muscle mass following bedrest. Healthy, young males will be fed in a continuous (no breaks in food supply) or intermittent (in boluses throughout the day) manner.
Sponsor: Maastricht University Medical Center

Current Primary Outcome: Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp) [ Time Frame: 7 days bedrest ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

• Change in muscle mass (measured as upper leg muscle cross-sectional area with CT scan) [ Time Frame: 7 days bedrest ]
  Via single-slice CT scan
• Change in lean tissue (measured via DEXA scan) [ Time Frame: 7 days bedrest ]
  Via DEXA

Original Secondary Outcome: Same as current

Information By: Maastricht University Medical Center

Dates:
Date Received: August 3, 2015
Date Started: October 2015
Date Completion:
Last Updated: July 26, 2016
Last Verified: July 2016