Clinical Trial: Role of Metformin on Muscle Health of Older Adults

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Metformin to Prevent Inactivity-induced Loss of Muscle Health During Aging

Brief Summary: Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin resistance adults though the mechanisms are not fully known. Metformin used as a preventive strategy to maintain muscle and metabolic health in bed ridden older adults has not been investigated.

Detailed Summary:
Sponsor: University of Utah

Current Primary Outcome: Muscle size [ Time Frame: Change in muscle size from baseline to 5-days of bed rest will be compared between groups after 5 days of bed rest ]

Change in muscle size from baseline to 5-days of bed rest (determined from a dual energy x-ray absorptiometry scan)


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Utah

Dates:
Date Received: March 22, 2017
Date Started: July 1, 2017
Date Completion: July 1, 2021
Last Updated: April 10, 2017
Last Verified: April 2017