Clinical Trial: Progressive Strength Training in Spinal Muscular Atrophy

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: Pilot Study of Progressive Strength Training in Spinal Muscular Atrophy

Brief Summary: The proposed feasibility study is necessary to test if children and young adults will participate in and adhere to a 12-week, home-based, supervised progressive strength training exercise program and to obtain preliminary data that will subsequently allow us to determine the safety and impact of strength training in spinal muscular atrophy. Our pilot study will address 3 aims: (1) Ascertain the feasibility of, and potential barriers to, participation in and adherence to a 12-week home-based, supervised, progressive strength training exercise program in children and young adults aged 5-21 years with SMA types II and III; (2) Determine the safety and tolerability of progressive strength training in a pilot study sample of children and young adults with SMA types II and III; and (3) Determine candidate outcome measures.

Detailed Summary:
Sponsor: University of Utah

Current Primary Outcome: Strength [ Time Frame: 12 weeks ]

Primary Outcome Measure was muscle strength. Strength was measured using a fixed myometry evaluation, quantitative muscle analysis (QMA). QMA utilizes a relative fixed point for the participant to exert effort. Each muscle of interest was tested using QMA.


Original Primary Outcome: Strength [ Time Frame: 12 weeks ]

maximum voluntary isometric contraction (MVIC): Hand held dynamometry (HHD) and quantitative muscle analysis (QMA)


Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Utah

Dates:
Date Received: October 19, 2010
Date Started: June 2010
Date Completion:
Last Updated: March 30, 2016
Last Verified: March 2016