Clinical Trial: Changes in Ocular Rigidity After Trabeculectomy in Patients With POAG

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Changes in Ocular Rigidity After Trabeculectomy in Patients With POAG or PEX

Brief Summary:

It has been hypothesized that the biomechanical properties of the optic nerve head and/or sclera play a role in the development of glaucoma. One approach of gaining insight into the biomechanical properties of the eye by the means of clinical studies is based on the Friedenwald equation, representing a pressure-volume relationship. This equation represents the so called ocular rigidity, which expresses the elasticity of the globe.

In order to be able to solve the equation, measurements of fundus pulsation amplitude (FPA) with laser interferometry and dynamic contour tonometric assessment of the pulse amplitude (PA) have to be performed.

In addition choroidal thickness will be assessed with OCT before and after trabeculectomy, since results in choroidal thickness measurements in patients with glaucoma are controversial.

The focus of this study lies on the changes of ocular rigidity and choroidal thickness after surgical trabeculectomy in patients with primary open angle glaucoma (POAG) or pseudoexfoliation glaucoma (PEX).


Detailed Summary:
Sponsor: Medical University of Vienna

Current Primary Outcome: Change in ocular rigidity [ Time Frame: Baseline and 28±7 days postoperative ]

Change in ocular rigidity after surgery


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Fundus pulsation amplitude [ Time Frame: Baseline and 28±7 days postoperative ]
  • Ocular pulse amplitude [ Time Frame: Baseline and 28±7 days postoperative ]
  • Mean arterial pressure [ Time Frame: Baseline and 28±7 days postoperative ]
  • Pulse rate [ Time Frame: Baseline and 28±7 days postoperative ]
  • Axial eye length [ Time Frame: Baseline and 28±7 days postoperative ]
  • choroidal thickness [ Time Frame: Baseline and 28±7 days postoperative ]


Original Secondary Outcome: Same as current

Information By: Medical University of Vienna

Dates:
Date Received: February 19, 2014
Date Started: October 2011
Date Completion:
Last Updated: December 1, 2016
Last Verified: December 2016