Clinical Trial: Effects of Continuous Passive Motion on the Spinal Circuitries and Its Adaptation in Patients With Spasticity Resulting From Upper Motor Neuron Lesions

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title:

Brief Summary: In animal and human studies, histochemical and physiological evidences showed that the muscle transferred from slow, fatigue-resistant muscle to fast, fatigable muscle after spinal cord injury. The alternation of muscular property was accompanied by the alternation of spinal circuitry property, and was related to the immobilization adaptation. Previous study showed that remobilization by continuous passive motion (CPM) for one month would restore the function of spinal circuitry in individual with chronic SCI. It is possible that long term application of CPM can reverse the adaptation of contractile properties of the paralyzed muscle after SCI. The purpose of this study is to investigate the effect of a four month CPM training on muscular properties in individuals with chronic SCI.

Detailed Summary:
Sponsor: Chang Gung University

Current Primary Outcome:

  • The contractile properties of the muscles [ Time Frame: Baseline, 1 month, 2 months, 3 months, and 4 months ]
    Measure of changes in contractile properties of soleus and tibialis anterior
  • Fatigue index [ Time Frame: Baseline, 1 month, 2 months, 3 months, and 4 months ]
    Measure of changes in Fatigue index of soleus and tibialis anterior.
  • Clinical muscle tone tests [ Time Frame: Baseline, 1 month, 2 months, 3 months, and 4 months ]
    Measure of changes in clinical muscle tone tests of soleus and tibialis anterior by Modified Ashworth Scale.
  • Patient Reported Impact of Spasticity Measure (PRISM) [ Time Frame: Baseline, 1 month, 2 months, 3 months, and 4 months ]
    Measure of changes in PRISM.
  • The potential adverse effects of ankle swelling [ Time Frame: Baseline, 1 month, 2 months, 3 months, and 4 months ]
    Measure of changes in the potential adverse effects of ankle swelling.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Chang Gung University

Dates:
Date Received: April 17, 2014
Date Started: January 2010
Date Completion:
Last Updated: April 23, 2014
Last Verified: April 2014