Clinical Trial: Tissue Perfusion Indices as Predictor of Outcome in Poly Trauma Patients

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Central Venous-arterial Carbon Dioxide Pressure Difference in Correlation to Dynamic Changes of Serum Lactate as an Indicator of Tissue Perfusion in Polytruama Patients

Brief Summary: Early intervention and resuscitation based upon a lot of clinical, laboratory findings make a big difference regarding outcome in poly trauma patients, the study uses the dynamic lactate change and the difference between arterial and venous CO2, oxygen tension or content as indicators for tissue perfusion.

Detailed Summary:

Poly trauma patients have high incidence of mortality and morbidity in spite of improvements and advances in facilities. However, no doubt that early resuscitation and interventions make a big difference upon the overall outcome.

A lot of methods, indices, laboratory and biomarkers have been utilized to evaluate the progress and quality of resuscitation and the early hospital interventions in such group of critically ill patients including central venous pressures, urine output, mixed venous oxygen saturation, and gastric tonometry. Most of recent means focus upon the regional tissue perfusion rather than global, however some researches have tried the difference between arterial and venous CO2,oxygen tension or content ( Pv -a co2& Pa -v O2 ) in addition to dynamic changes in lactate(3) as predictors for tissue perfusion in sepsis patients after establishment of sepsis campaign (bundle).


Sponsor: Assiut University

Current Primary Outcome:

  • the difference between partial pressure of oxygen in arterial and venous blood [ Time Frame: 6 hours ]
  • the difference between partial pressure of carbon dioxide in arterial and venous blood [ Time Frame: 6 hours ]
  • serum level of lactate and its changes [ Time Frame: 6 hours ]
    as an index for tissue oxygenation


Original Primary Outcome: sufficient tissue perfusion indices [ Time Frame: 7 days ]

to evaluate that end organ functions are not affected


Current Secondary Outcome:

  • Kidney function [ Time Frame: 72 hours ]
    serum creatinine in mg/ dl and urine output/ hour
  • hemodynamic stability including pulse rate and mean arterial blood pressure [ Time Frame: 72 hours ]
  • duration of stay in the critical care unit [ Time Frame: 72 hours ]


Original Secondary Outcome:

Information By: Assiut University

Dates:
Date Received: March 23, 2016
Date Started: May 2016
Date Completion: January 2018
Last Updated: September 17, 2016
Last Verified: April 2016