Clinical Trial: Cognitive and Behavioral Dysexecutive Syndrome in Multiple System Atrophy

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Comparison of Cognitive and Behavioral Dysexecutive Syndrome Between Parkinsonian Form and Cerebellar Form of Multiple System Atrophy and Analysis of Correlates With an Im

Brief Summary: The main objective of the study is to compare the score to the Behavioral Dysexecutive Syndrome Inventory (BDSI) between Parkinsonian Multiple system Atrophy MSA-P patients and cerebellar Multiple System Atrophy (MSA-C) patients matched on disease duration, age (± 3 years) and sex .

Detailed Summary:

Multiple system atrophy (MSA) is a rare neurodegenerative disorder which is characterized by a variable combination of parkinsonism, cerebellar dysfunction, autonomic failure, and additional signs. According to the consensus criteria for the diagnosis of MSA, the presence of dementia is considered an exclusion criteria. However, several studies have reported cognitive impairment in patients with MSA, dominated by a dysexecutive syndrome. Some studies have compared the cognitive profile of MSA-P patients and MSA-C but any have studied the behavioral dysexecutive syndrome in this population. In 2010, the GREFFEX has established criteria for dysexecutive syndrome and described two distinct parts: the dysexecutive syndrome and cognitive behavioral dysexecutive syndrome. Our clinical impression is that according to the type of MSA, the dysexecutive syndrome seems to be different : the MSA-P patients seem to have a cognitive dysexecutive syndrome and the MSA-C patients a behavioral dysexecutive syndrome.

We want to compare the BDSI score between MSA-P patients and MSA-C patients matched on disease duration, age and sex The specific involvement of the cerebellum in behavioral disorders could explain the behavioral differences experienced by clinicians caring for these patients but never demonstrated. The presence of these disorders could have an impact on the relationship between the patient and the caregiver. In addition, few studies have correlated with cognitive imagery data. Therefore, the exact areas involved in cognitive and behavioral MSApatients remain poorly understood.


Sponsor: University Hospital, Bordeaux

Current Primary Outcome: Behavioral Dysexecutive Syndrome Inventory scores [ Time Frame: At inclusion (day 0) ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • To compare the subscores of the BDSI between MSA-P patients and MSA-C patients. [ Time Frame: At inclusion (Day 0) ]
  • To compare the cognitive tests exploring the cognitive dysexecutive syndrome between MSA-P patients and MSA-C patients. [ Time Frame: At inclusion (Day 0) ]
    • Trail making Test
    • Stroop Test
    • Modfied Card Sorting Test
    • Brixton Test
    • Verbal fluency Test
    • Six Elements Test
  • To research correlations between scores UMSARS and cognitive and behavioral scores for MSA-P patients and MSA-C patients. [ Time Frame: At inclusion (Day 0) ]
    Assessment using the Behavioral Dysexecutive Syndrome Inventory
  • To compare atrophied brain areas, the anatomic and functional abnormalities of neural networks between MSA-P patients and MSA-C patients. [ Time Frame: At inclusion (Day 0) ]
  • To research correlations between imaging abnormalities and cognitive test performance in MSA patients. [ Time Frame: At inclusion (day 0) ]
  • Actigraphy [ Time Frame: During 7 days after inclusion ]

    Sleep analysis :

    Sleep / wake cycles and sleep fragmentation



Original Secondary Outcome: Same as current

Information By: University Hospital, Bordeaux

Dates:
Date Received: July 1, 2014
Date Started: May 2014
Date Completion: May 2016
Last Updated: January 8, 2015
Last Verified: January 2015