Clinical Trial: Usefulness of Interferon-gamma Release Assay in Diagnosing Pulmonary Nodules
Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational
Official Title: Usefulness of Interferon-gamma Release Assay in Diagnosing Pulmonary Nodules
Brief Summary:
Among the causes of the solitary pulmonary nodule (SPN), benign causes including tuberculosis was noted on 15 to 60 percents in various studies.
Although the characteristics of chest imaging is helpful in diagnosis and percutaneous needle biopsy for pulmonary nodule has been represented high diagnostic yield in many reports, but still surgical biopsy has been needed in definite diagnosis of pulmonary nodules in many cases.
The aim of this study is to evaluate the usefulness of interferon-gamma release assay in addition to the percutaneous needle biopsy, in diagnosis of pulmonary nodules.
Detailed Summary:
Among the patients who failed to diagnosis by percutaneous needle biopsy and needed to have Surgical biopsy, thirty percents of the patients were diagnosed as benign nodules and about six percents were diagnosed as tuberculosis in Seoul National University Hospital during 2007-2008.
The investigators want to know whether conducting an interferon-gamma release assay in addition to percutaneous needle biopsy is helpful in diagnosis of lung nodules.
Sponsor: Seoul National University Hospital
Current Primary Outcome: Positive rate of the interferon-gamma release assay [ Time Frame: within 36hrs after blood sampling ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Positive rate of the Tuberculin skin test [ Time Frame: 48hours after tuberculin skin test ]
Original Secondary Outcome: Same as current
Information By: Seoul National University Hospital
Dates:
Date Received: June 21, 2010
Date Started: June 2010
Date Completion: December 2010
Last Updated: June 22, 2010
Last Verified: June 2010