Clinical Trial: Treatment of Zollinger-Ellison Syndrome With Prevacid

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Long-Term Study of the Efficacy and Safety of Lansoprazole in the Treatment of Zollinger-Ellison and Other Acid Hypersecretors

Brief Summary: The purpose of this study is to study the safety and efficacy of high dose Prevacid in the long-term treatment of patients who secrete abnormally large amounts of gastric acid.

Detailed Summary: The aim of this protocol is to study the medical management of acid hypersecretory states including Zollinger-Ellison using Prevacid. The immediate objective is to heal peptic ulcers and eliminate symptoms and in the long term to prevent relapse of symptoms, lesions and complications. Other objectives include observation of the efficacy in controlling gastric acid production and of the safety of high dose, long-term use of Prevacid.
Sponsor: Charles Mel Wilcox, MD

Current Primary Outcome: Long-term Medical(Non-surgical)Control of Gastric Acid Production Assessed From Time of Study Enrollment, up to 240 Months Post Enrollment. [ Time Frame: up to 240 months from study enrollment ]

number of participants with control of gastric acid production


Original Primary Outcome:

  • Long-term medical(non-surgical)control of gastric acid production
  • Medical control of symptoms


Current Secondary Outcome: The Median Survival From the Time of Diagnosis. [ Time Frame: survival or up to 240 months ]

The median survival from the time of diagnosis


Original Secondary Outcome: Prevention of relapse of symptoms, lesions & complications.

Information By: University of Alabama at Birmingham

Dates:
Date Received: September 13, 2005
Date Started: March 2003
Date Completion:
Last Updated: October 23, 2012
Last Verified: October 2012