Clinical Trial: Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke

Brief Summary: The aim of this study is to investigate the proportion of patients with moyamoya disease among the patients who were diagnosed as having intracranial atherosclerotic stroke. To do this, biomarkers (gene and imaging) for moyamoya disease are tested and follow up angiography are performed during follow up (in selected patients).

Detailed Summary:

  1. Purpose Both moyamoya disease (MMD) and intracranial atherosclerotic stenosis (ICAS) are more prevalent in Asians than in Westerners, although the reason for the race-ethnic differences is unsettled. It is possible that patients with adult-onset MMD were misclassified as having ICAS, which may in part explain the high prevalence of intracranial atherosclerosis in Asians. It is important to differentiation between these two diseases because MMD and ICAS have differential therapeutic strategies (surgical revascularization in MMD vs. the use of antithrombotics/statins and stenting in ICAS). The ring finger 213 (RNF213) was recently identified as a susceptibility gene for MMD in East Asians. Characteristic high-resolution (HR) MRI findings of MMD and ICAS have recently been reported. The aim of this study is to investigate the proportion of patients with moyamoya disease among the patients who were diagnosed as having intracranial atherosclerotic stroke. To do this, biomarkers (gene and imaging) for moyamoya disease are tested and follow up angiography are performed during follow up (in selected patients).
  2. Conditions: Stroke, intracranial occlusive lesion
  3. Intervention: None
  4. Study period: Jan 22, 2014 ~ Dec 31, 2016
  5. Study design: Observational model Time perspective: Retrospective-Prospective

Sponsor: Samsung Medical Center

Current Primary Outcome: Frequency of RNF213 gene variants and HR-MRI findings in patients with intracranial atherosclerosis [ Time Frame: Anytime during study period (in intracranial atherosclerosis, HR-MRI findings within 2 weeks) ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Frequency of typical angiographic findings of moyamoya disease at follow up conventional angiography in patients with intracranial atherosclerosis who showed typical gene and imaging biomarkers of moyamoya disease [ Time Frame: Within 2 years ]

Original Secondary Outcome: Same as current

Information By: Samsung Medical Center

Dates:
Date Received: February 26, 2014
Date Started: January 2014
Date Completion: December 2019
Last Updated: April 24, 2017
Last Verified: April 2017