Clinical Trial: Does Thiamine Help Vomiting and Nausea in Pregnancy?
Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional
Official Title: Comparison Between the Treatment of Thiamine and Promethazine for Improving Vomiting and Nausea in Pregnancy
Brief Summary: There are different treatments for nausea and vomiting in pregnancy. According to the ACOG recommendations, promethazine is the first line of parenteral treatment after oral treatment had failed. Thiamine is given to prevent wernicke encephalopathy. This research try to find out whether thiamine helps the vomiting and nausea as well, by comparing the response to thiamine and promethazine in women who suffer from nausea and vomiting in pregnancy.
Detailed Summary:
- Research groups: pregnant women eho visit the emergency room for nausea and vomiting in pregnancy, pregnancy age 12 weeks or less
- After basic examinations and hydration, the women will randomized to thiamine or promethazine treatment.
- If no improvement is shown, the patient will be treated with the other drug
- The patients will be interviewed on their current visit and every two weeks until 14th week of gestation
- The interview includes medical history and details about their illness, other treatments, hospitalization etc.
Sponsor: HaEmek Medical Center, Israel
Current Primary Outcome: the improvement in nausea and/or vomiting after treatment [ Time Frame: 2 months after first visit in ER (until 14 week of pregnancy) ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: HaEmek Medical Center, Israel
Dates:
Date Received: February 18, 2009
Date Started: February 2009
Date Completion:
Last Updated: June 21, 2015
Last Verified: June 2015
