Clinical Trial: Beating Versus Arrested Heart for Mitral Valve Replacement
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Clinical and Ultramicroscopic Myocardial Randomized Study of On-Pump Beating Heart Mitral Valve Replacement
Brief Summary: The purpose of this study is to evaluate the immediately clinic and ultramicroscopic myocardial cellular ischemia and reperfusion to replace of the mitral valve using arrested heart versus on-pump empty beating heart surgical techniques.
Detailed Summary: During open-heart surgery prevention of ischemia and reperfusion following cardioplegic arrest are essential for myocardial protection. Beating heart surgery on normothermic bypass simulates physiologic cardiac status and is good method for myocardial protection. A comparison of both available techniques for valve replacement arrested heart versus on-pump empty beating heart of the clinical and ultramicroscopic myocardial alterations will allowed to better understand myocardial protection because eliminated the use of cardioplegia and the corollary risk of ischemic reperfusion injury.
Sponsor: Federal University of Bahia
Current Primary Outcome: mitral valve replacement [ Time Frame: 1hour , 3 hours and 1 hour after surgery procedure ]
Original Primary Outcome: Cardiac dysfunction [ Time Frame: 1hour , 3 hours and 1 hour after surgery procedure ]
Current Secondary Outcome: Ultramicroscopic evidences of ischemia [ Time Frame: 1hour, 3 hours and 1 hour after aortic clamping ]
Original Secondary Outcome: Same as current
Information By: Federal University of Bahia
Dates:
Date Received: July 10, 2012
Date Started: April 2010
Date Completion:
Last Updated: July 17, 2012
Last Verified: July 2012