Clinical Trial: Genetic Basis of Mitral Valve Prolapse

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Genetic Basis of Mitral Valve Prolapse

Brief Summary: The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions. This requires recruiting large families who may have MVP linked to these or other chromosomes; and obtaining DNA samples from 1,000-1,500 individually affected patients to study the relation between DNA markers throughout the genome and MVP. It is our expectation that the results of this study will lead to the discovery of gene(s) responsible for MVP. This will lead to improved understanding of the disease and, in turn, improved ability to treat and prevent progression in genetically susceptible individuals.

Detailed Summary: This is a genome-wide association study.
Sponsor: Massachusetts General Hospital

Current Primary Outcome: Discovery of the genetic basis of Mitral Valve Prolapse [ Time Frame: 5 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Massachusetts General Hospital

Dates:
Date Received: October 30, 2012
Date Started: January 1999
Date Completion: December 2020
Last Updated: February 10, 2017
Last Verified: February 2017