Clinical Trial: Oral Tolerance in Cow’s Milk Allergy in the Infant

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Oral Tolerance in Cow’s Milk Allergy in the Infant: Role of CD4+CD25+ T Cells and Intestinal Microflora

Brief Summary:

This study aims to determine if there is a link between cow’s milk allergy in infants and regulatory T cells dysfunction that should be transient in infant acquiring oral tolerance after 12 month avoiding food and persistent in others.

Cow’s milk allergy is evaluated by basophils activation test, T cells activation test, specific humoral response (IgA, IgE, IgG) in allergic infants before and after 12 month avoiding food, before and after low dose milk exposure, before and after oral challenge.

Number and function of regulatory T cells and microflora composition are measured at the same time.

Allergic infants are compared to age matched control group.

Detailed Summary:
Sponsor: Hospices Civils de Lyon

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Hospices Civils de Lyon

Dates:
Date Received: March 1, 2006
Date Started: March 2006
Date Completion:
Last Updated: April 26, 2007
Last Verified: April 2007