Clinical Trial: Functional MRI (fMRI) in CGRP Induced Migraine

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Functional MRI (fMRI) in Patients With Migraine Without Aura Provoked by

Brief Summary:

In patients known with migraine without aura a migraine headache or migraine like headache will be induced by infusion of calcitonin gene related peptide (CGRP). The patients will then be stimulated with noxious heat via a thermode placed at the forehead. At the same time the Blood-oxygenation-level-dependent (BOLD) response will be measured via functional magnetic resonance imaging (fMRI), to estimate the central-nervous pain response. The regions of interest (ROI) will be thalamic region and medulla oblongata.

Then the patients will be given pain relif in form of injection of sumatriptan and the effect of this will also be registered via measuring the BOLD response at the RIO's previously defined. A 3-Tesla MRI scanner will be used in this trail.

This study will give us key knowledge of the trigeminal pain pathway and the central processing i.e sensitization during a migraine attach.


Detailed Summary:
Sponsor: Danish Headache Center

Current Primary Outcome:

  • Changes in BOLD response before and after CGRP infusion.
  • Changes in BOLD response before and after injection of sumatriptan.


Original Primary Outcome:

  • Changes in BOLD respons before and after CGRP infusion.
  • Changes in BOLD respons before and after injection of sumatriptan.


Current Secondary Outcome:

Original Secondary Outcome:

Information By: Danish Headache Center

Dates:
Date Received: August 11, 2006
Date Started: September 2006
Date Completion:
Last Updated: January 27, 2009
Last Verified: January 2009