Clinical Trial: Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow by Hypoxia
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Study of Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries by Hypoxia in a Humane Experimental Migraine Model
Brief Summary:
In this study the investigators will investigate the following hypothesis
- that hypoxia induce migraine headache and migraine aura
- the aura phase is associated with a spreading reduction in cerebral blood flow
- the migraine headache is associated with dilatation of intra- and extracerebral arteries
- the migraine headache is associated with changes in brain metabolism
- the pre-ictal stage of a migraine attack with aura is associated with specific patterns in neural activity.
Detailed Summary:
To investigate migraine with aura symptoms during and after hypoxia.
With magnetic resonance imaging the investigators will investigate changes in
- regional cerebral blood flow (rCBF)
- resting state functional connectivity
- circumference of the middle cerebral artery(MCA), internal carotic artery, superficial temporal artery, medial meningeal artery, external carotic artery
- brain metabolism
And compare these changes with a aged match healthy control group.
Sponsor: Danish Headache Center
Current Primary Outcome: Headache and aura [ Time Frame: 24 h ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- artery circumference [ Time Frame: Baseline, 120 and 200 min ]Hypoxia induced changes in intra- and extracranial circumference
- Cerebral blood flow [ Time Frame: Baseline, 120 and 200 min ]Hypoxia induced changes in cerebral blood flow
- BOLD response in visual cortex [ Time Frame: Baseline, 170 min and 220 min ]Hypoxia induced changes in BOLD response
- Brain metabolism [ Time Frame: Baseline, 180 min and 230 min post hypoxia ]Hypoxia induced changes in brain metabolism
Original Secondary Outcome:
- artery circumference [ Time Frame: Baseline, 90 and 180 min ]Hypoxia induced changes in intra- and extracranial circumference
- Cerebral blood flow [ Time Frame: Baseline, 90 and 180 min ]Hypoxia induced changes in cerebral blood flow
- Resting state functional connectivity [ Time Frame: Baseline and approximately 15 min post hypoxia ]To identify specific patterns in resting state functional connectivity (RSFC) in the pre-ictal stage of a migraine attack induced by hypoxia
Information By: Danish Headache Center
Dates:
Date Received: June 21, 2013
Date Started: April 2013
Date Completion:
Last Updated: February 11, 2015
Last Verified: February 2015