Clinical Trial: Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow by Hypoxia

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Study of Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries by Hypoxia in a Humane Experimental Migraine Model

Brief Summary:

In this study the investigators will investigate the following hypothesis

  • that hypoxia induce migraine headache and migraine aura
  • the aura phase is associated with a spreading reduction in cerebral blood flow
  • the migraine headache is associated with dilatation of intra- and extracerebral arteries
  • the migraine headache is associated with changes in brain metabolism
  • the pre-ictal stage of a migraine attack with aura is associated with specific patterns in neural activity.

Detailed Summary:

To investigate migraine with aura symptoms during and after hypoxia.

With magnetic resonance imaging the investigators will investigate changes in

  • regional cerebral blood flow (rCBF)
  • resting state functional connectivity
  • circumference of the middle cerebral artery(MCA), internal carotic artery, superficial temporal artery, medial meningeal artery, external carotic artery
  • brain metabolism

And compare these changes with a aged match healthy control group.


Sponsor: Danish Headache Center

Current Primary Outcome: Headache and aura [ Time Frame: 24 h ]

Comparison between hypoxia and placebo (atmospheric air)


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • artery circumference [ Time Frame: Baseline, 120 and 200 min ]
    Hypoxia induced changes in intra- and extracranial circumference
  • Cerebral blood flow [ Time Frame: Baseline, 120 and 200 min ]
    Hypoxia induced changes in cerebral blood flow
  • BOLD response in visual cortex [ Time Frame: Baseline, 170 min and 220 min ]
    Hypoxia induced changes in BOLD response
  • Brain metabolism [ Time Frame: Baseline, 180 min and 230 min post hypoxia ]
    Hypoxia induced changes in brain metabolism


Original Secondary Outcome:

  • artery circumference [ Time Frame: Baseline, 90 and 180 min ]
    Hypoxia induced changes in intra- and extracranial circumference
  • Cerebral blood flow [ Time Frame: Baseline, 90 and 180 min ]
    Hypoxia induced changes in cerebral blood flow
  • Resting state functional connectivity [ Time Frame: Baseline and approximately 15 min post hypoxia ]
    To identify specific patterns in resting state functional connectivity (RSFC) in the pre-ictal stage of a migraine attack induced by hypoxia


Information By: Danish Headache Center

Dates:
Date Received: June 21, 2013
Date Started: April 2013
Date Completion:
Last Updated: February 11, 2015
Last Verified: February 2015