Clinical Trial: Migraine and Endothelial Dysfunction

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Migraine and Endothelial Dysfunction

Brief Summary: Recently, there is evidence that endothelial activation and dysfunction are associated with migraine, especially in female migraineurs with aura. Our objectives were to determine whether novel endothelial function markers are altered in female migraineurs with aura compared to age-matched controls.

Detailed Summary:

Our objectives were to determine whether novel endothelial function methods and novel markers of endothelial activation are associated with migraine in female migraineurs with aura.

Migraine is an independent risk factor for stroke, especially in young women with aura symptoms. Endothelial dysfunction is a risk factor for cardiovascular diseases. Recent studies suggest that there is a link between migraine with aura and endothelial activation, dysfunction and impaired vascular reactivity.

In this case-control study the investigators examine several novel biomarkers of endothelial function such as endothelial progenitor cells and endothelial microparticles as well as novel methods such as reactive hyperemic peripheral arterial tonometry in female migraineurs with aura and age-matched controls.


Sponsor: Charite University, Berlin, Germany

Current Primary Outcome: Endothelial Microparticles [ Time Frame: baseline ]

Levels of endothelial microparticlel in the peripheral blood using flow cytometry


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Levels of circulating Endothelial Progenitor Cells [ Time Frame: baseline ]
    Levels of cEPC (CD34+/CD133+/VGF2R/CD31) in % of mononuclear cells using flow cytometry
  • Digital pulse volume change [ Time Frame: baseline ]
    Digital pulse volume change (with RH PAT as non invasive measurement (PAT-ratio; ENDOPAT, Itamar Medical Ltd.) for non-invasive, peripheral endothelial function


Original Secondary Outcome: Same as current

Information By: Charite University, Berlin, Germany

Dates:
Date Received: July 5, 2011
Date Started: October 2010
Date Completion: September 2011
Last Updated: July 6, 2011
Last Verified: June 2011