Clinical Trial: Brainstem Grey Matter and Cerebral Autoregulation in Migraine With Aura.

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Brainstem Grey Matter and Cerebral Autoregulation in Migraine With Aura : a MRI and Transcranial Doppler.

Brief Summary:

Migraine with aura (MA) is an independent risk factor for stroke and is associated with silent brain infracts and T2 white matter hyperintensities on MRI. Previous studies using Transcranial Doppler (TCD) have shown an impairment of cerebral autoregulation in MA patients. Studies with positron emission tomography have demonstrated an activation of brain stem areas during migraine attack. An increased density of brain stem grey matter as measured on MRI with voxel based morphometry (VBM) has been found in MA patients. As brain arteries and arterioles are innervated by ascending tracts from aminergic brainstem nuclei, th study hypothesize a negative correlation between the density of brainstem nuclei and the efficiency of cerebral autoregulation in MA patients compared with controls.

Brainstem grey matter density will be studied with a MRI Philips 3 Tesla with a 32-channel antenna and voxel-based morphometry (VBM) cerebral autoregulation will be measured in the time domain using Transcranial Doppler (TCD) and the Mx method.

MA patients will be studied in a headache-free period. MRI and Transcranial Doppler (TCD) are non-invasive technics and will be performed on the same day.


Detailed Summary:
Sponsor: University Hospital, Toulouse

Current Primary Outcome: Correlation between the density of the pontine grey matter evaluated with resonance magnetic imaging, and cerebral autoregulation measured with Transcranial Doppler in migraine with aura patients and controls. [ Time Frame: 30 days after the pre-inclusion visit ]

Resonance magnetic imaging use voxel base morphometry and Transcranial doppler use the coefficient mx calculation.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Comparison of brainstem grey matter density between migraine with aura patients and controls with magnetic resonance imaging [ Time Frame: 30 days after pre-inclusion visit ]
    Comparison will be done with software using voxel based morphometry (VBM) function in addition of imaging with resonance magnetic imaging.
  • Comparison of cerebral autoregulation between migraine with aura patients and controls with Transcranial Doppler [ Time Frame: 30 days after pre-inclusion visit ]
    Comparison will be done using the calculation of mx coefficient in addition of imaging with Transcranial Doppler.
  • Comparison of cerebrovascular reactivity to carbon dioxide between migraine with aura patients and controls with Transcranial Doppler [ Time Frame: 30 days after pre-inclusion visit ]
    Comparison will be done using voluntary apnea test in addition of imaging with Transcranial Doppler.
  • Comparison of morphological abnormalities between migraine with aura patients and controls with resonance magnetic imaging. [ Time Frame: 30 days after pre-inclusion visit ]
    Comparison will be done using T2 white matter hyperintensities and silent brain infracts on resonance magnetic imaging.
  • Comparison of baroreflex sensitivity between migraine with aura patients and controls with Transcranial Doppler [ Time Frame: 30 days after pre-inclusion visit ]
  • Association between grey matter density and morphological abnormalities on resonance magnetic imaging [ Time Frame: 30 days after pre-inclusion visit ]
    Association will be determined using T2 white matter hyperintensities, silent brain infracts and voxel based morphometry function of software
  • Association between cerebral autoregulation and morphological abnormalities on magnetic resonance imaging [ Time Frame: 30 days after pre-inclusion visit ]
    Association will be determined using T2 white matter hyperintensities, silent brain infracts and calculation of mx coefficient
  • Relation between baroreflex sensitivity and cerebral autoregulation with Transcranial Doppler. [ Time Frame: 30 days after pre-inclusion visit ]
    Relation will be determined using the calculation of mx coefficient in addition of imaging with Transcranial Doppler


Original Secondary Outcome: Same as current

Information By: University Hospital, Toulouse

Dates:
Date Received: March 9, 2016
Date Started: May 2016
Date Completion:
Last Updated: May 17, 2017
Last Verified: May 2017